Scientists have discovered a new way to slow down aging, and it doesn’t involve a magic potion or a mythical fountain of youth. Instead, the key lies within our own bodies, specifically in our white blood cells called T cells.

A new study published in Nature Aging reveals that T cells can be reprogrammed to become powerful anti-aging agents known as CAR (chimeric antigen receptor) T cells. When tested on mice, these CAR T cells rejuvenated aging mice and slowed down aging in young mice. The mice treated with CAR T cells lived healthier lives, had lower body weights, improved metabolism and glucose tolerance, and increased physical activity.

The researchers are calling this treatment the ‘living drug’ because the genetically modified CAR T cells actively attack and eliminate a group of cells called ‘senescent cells’. Senescent cells are damaged or malfunctioning cells that accumulate in our bodies as we age and contribute to aging-related diseases. By eliminating these senescent cells, the CAR T cells can help slow down the aging process and improve overall health.

This discovery opens up exciting possibilities for developing new therapies to slow down aging and prevent or treat age-related diseases.

As we age, we accumulate senescent cells in the body. These cells contribute to various health issues such as obesity and diabetes. Inflammation levels increase as these cells accumulate. CAR T cells, however, offer a potential solution by eliminating senescent cells, which could slow down the aging process.

CAR T cells have already been approved in the United States for treating blood cancer. However, this is the first time researchers have demonstrated that CAR T cells can also slow down and even reduce the effects of aging. While drugs to eliminate senescent cells exist, they require repeated administration. In contrast, CAR T cells have long-lasting effects, potentially providing lifelong protection with a single dose.

The scientists involved in this research are excited about the potential of CAR T cells in promoting healthy aging. They will continue to investigate whether CAR T cells not only improve the quality of life but also extend lifespan.